Identification of the anti-mycobacterial functional properties of piperidinol derivatives.

ABSTRACT:

Background and purpose

Tuberculosis (TB) remains a major global health threat and is now the leading cause of death from a single infectious agent worldwide. The current TB drug regimen is inadequate, and new anti-tubercular agents are urgently required to be able to successfully combat the increasing prevalence of drug-resistant TB. The purpose of this study was to investigate a piperidinol compound derivative that is highly active against the Mycobacterium tuberculosis bacillus.

Experimental approach

The antibacterial properties of the piperidinol compound and its corresponding bis-Mannich base analogue were evaluated against M. smegmatis and Gram-negative organisms. Cytotoxicity studies were undertaken in order to determine the selectivity index for these compounds. Spont

SUBMITTER: Guy CS 

PROVIDER: S-EPMC5481654 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature