Ontology highlight
ABSTRACT:
SUBMITTER: Wu D
PROVIDER: S-EPMC5481770 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Nature communications 20170616
Regulatory T (T<sub>reg</sub>) cells are a distinct T-cell lineage characterized by sustained Foxp3 expression and potent suppressor function, but the upstream dominant factors that preserve T<sub>reg</sub> lineage-specific features are mostly unknown. Here, we show that Lkb1 maintains T<sub>reg</sub> cell lineage identity by stabilizing Foxp3 expression and enforcing suppressor function. Upon T-cell receptor (TCR) stimulation Lkb1 protein expression is upregulated in T<sub>reg</sub> cells but n ...[more]