Molecular Engineering of Robustness and Resilience in Enzymatic Reaction Networks.

ABSTRACT: Living systems rely on complex networks of chemical reactions to control the concentrations of molecules in space and time. Despite the enormous complexity in biological networks, it is possible to identify network motifs that lead to functional outputs such as bistability or oscillations. One of the greatest challenges in chemistry is the creation of such functionality from chemical reactions. A key limitation is our lack of understanding of how molecular structure impacts on the dynamics of chemical reaction networks, preventing the design of networks that are robust (i.e., function in a large parameter space) and resilient (i.e., reach their out-of-equilibrium function rapidly). Here we demonstrate that reaction rates of individual reactions in the network can control the dynamics by wh

SUBMITTER: Wong ASY 

PROVIDER: S-EPMC5481813 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature