Programming of mouse obesity by maternal exposure to concentrated ambient fine particles.

ABSTRACT:

Background

Many diseases including obesity may originate through alterations in the early-life environment that interrupts fetal development. Increasing evidence has shown that exposure to ambient fine particles (PM_2.5) is associated with abnormal fetal development. However, its long-term metabolic effects on offspring have not been systematically investigated.

Results

To determine if maternal exposure to PM_2.5 programs offspring obesity, female C57Bl/6j mice were exposed to filtered air (FA) or concentrated ambient PM_2.5 (CAP) during pre-conception, pregnancy, and lactation, and the developmental and metabolic responses of offspring were assessed. The growth trajectory of offspring revealed that maternal exposure to CAP significantly decreas

SUBMITTER: Chen M 

PROVIDER: S-EPMC5481884 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature