Establishment of an orthotopic patient-derived xenograft mouse model using uveal melanoma hepatic metastasis.

ABSTRACT:

Background

Metastatic uveal melanoma is a highly fatal disease; most patients die from their hepatic metastasis within 1 year. A major drawback in the development of new treatments for metastatic uveal melanoma is the difficulty in obtaining appropriate cell lines and the lack of appropriate animal models. Patient-derived xenograft (PDX) tumor models, bearing ectopically implanted tumors at a subcutaneous site, have been developed. However, these ectopically implanted PDX models have obstacles to translational research, including a low engraftment rate, slow tumor growth, and biological changes after multiple passages due to the different microenvironment. To overcome these limitations, we developed a new method to directly transplant biopsy specimens to the liver of immunocompromi

SUBMITTER: Kageyama K 

PROVIDER: S-EPMC5481921 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature