Genome-wide analysis of DNA methylation in hypothalamus and ovary of Capra hircus.

ABSTRACT:

Background

DNA methylation is a frequently studied epigenetic modification due to its role in regulating gene expression and hence in biological processes and in determining phenotypic plasticity in organisms. Rudimentary DNA methylation patterns for some livestock species are publically available: among these, goat methylome deserves to be further explored.

Results

Genome-wide DNA methylation maps of the hypothalamus and ovary from Saanen goats were generated using Methyl-CpG binding domain protein sequencing (MBD-seq). Analysis of DNA methylation patterns indicate that the majority of methylation peaks found within genes are located gene body regions, for both organs. Analysis of the distribution of methylated sites per chromosome showed that chromosome X had the lowest nu

SUBMITTER: Frattini S 

PROVIDER: S-EPMC5481934 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature