A rapid and quantitative method to detect human circulating tumor cells in a preclinical animal model.

ABSTRACT:

Background

As cancer metastasis is the deadliest aspect of cancer, causing 90% of human deaths, evaluating the molecular mechanisms underlying this process is the major interest to those in the drug development field. Both therapeutic target identification and proof-of-concept experimentation in anti-cancer drug development require appropriate animal models, such as xenograft tumor transplantation in transgenic and knockout mice. In the progression of cancer metastasis, circulating tumor cells (CTCs) are the most critical factor in determining the prognosis of cancer patients. Several studies have demonstrated that measuring CTC-specific markers in a clinical setting (e.g., flow cytometry) can provide a current status of cancer development in patients. However, this useful techniqu

SUBMITTER: Tu SH 

PROVIDER: S-EPMC5481956 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature