Glucose Peaks and the Risk of Dementia and 20-Year Cognitive Decline.

ABSTRACT:

Objective

Hemoglobin A_1c (HbA_1c), a measure of average blood glucose level, is associated with the risk of dementia and cognitive impairment. However, the role of glycemic variability or glucose excursions in this association is unclear. We examined the association of glucose peaks in midlife, as determined by the measurement of 1,5-anhydroglucitol (1,5-AG) level, with the risk of dementia and 20-year cognitive decline.

Research design and methods

Nearly 13,000 participants from the Atherosclerosis Risk in Communities (ARIC) study were examined. Dementia was ascertained from surveillance, neuropsychological testing, telephone calls with participants or their proxies, or death certificate dementia codes. Cognitive function was assessed using three neurop

SUBMITTER: Rawlings AM 

PROVIDER: S-EPMC5481977 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature