Maternal BMI and Glycemia Impact the Fetal Metabolome.

ABSTRACT:

Objective

We used targeted metabolomics to determine associations of maternal BMI and glucose levels with cord blood metabolites and associations of cord blood metabolites with newborn birth weight and adiposity in mother-offspring dyads.

Research design and methods

Targeted metabolomic assays were performed on cord blood serum samples from European ancestry, Afro-Caribbean, Thai, and Mexican American newborns (400 from each ancestry group) whose mothers participated in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study and who had anthropometric measurements at birth.

Results

Meta-analysis across the four cohorts demonstrated significant correlation of all cord blood metabolites analyzed with maternal fasting levels of the same metabolites at ∼28 weeks' ges

SUBMITTER: Lowe WL 

PROVIDER: S-EPMC5481987 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature