Metformin ameliorates hepatic steatosis and improves the induction of autophagy in HFD‑induced obese mice.

ABSTRACT: The present study aimed to investigate the effect of metformin on the induction of autophagy in the liver and adipose tissues of a mouse model of obesity. C57BL/6J mice were fed a high‑fat diet (HFD) for 12 weeks to induce obesity‑associated hepatic steatosis, and treated with metformin (150 mg/kg/d) by intraperitoneal injection for the final 4 weeks of HFD feeding. Body weight was recorded weekly, and the food intake of the mice was recorded daily during the treatment period. Liver and adipose tissues were harvested for histological and molecular analyses. The results revealed that metformin significantly reduced body weight without altering food intake in the HFD mice, particularly in the epididymal white adipose tissue (eWAT). Metformin treatment ameliorated HFD‑induced hepatic steatosi

SUBMITTER: Li M 

PROVIDER: S-EPMC5482143 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature