Risk of Cardiovascular Disease from Cumulative Cigarette Use and the Impact of Smoking Intensity.

ABSTRACT:

Background

Relative risks (RRs) for cardiovascular disease (CVD) by smoking rate exhibit a concave pattern, with RRs in low rate smokers exceeding a linear extrapolation from higher rate smokers. However, cigarettes/day does not by itself fully characterize smoking-related risks. A reexamination of the concave pattern using a comprehensive representation of smoking may enhance insights.

Methods

Data were from the Atherosclerosis Risk in Communities (ARIC) Study, a prospective cohort enrolled in four areas of the US in 1987-1989. Follow-up was through 2008. Analyses included 14,233 participants, 245,915 person-years, and 3,411 CVD events.

Results

The concave RRs with cigarettes/day were consistent with cigarettes/day modifying a linear RR association of pack-years with

SUBMITTER: Lubin JH 

PROVIDER: S-EPMC5482174 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature