The Diverse Roles of Arrestin Scaffolds in G Protein-Coupled Receptor Signaling.

ABSTRACT: The visual/β-arrestins, a small family of proteins originally described for their role in the desensitization and intracellular trafficking of G protein-coupled receptors (GPCRs), have emerged as key regulators of multiple signaling pathways. Evolutionarily related to a larger group of regulatory scaffolds that share a common arrestin fold, the visual/β-arrestins acquired the capacity to detect and bind activated GPCRs on the plasma membrane, which enables them to control GPCR desensitization, internalization, and intracellular trafficking. By acting as scaffolds that bind key pathway intermediates, visual/β-arrestins both influence the tonic level of pathway activity in cells and, in some cases, serve as ligand-regulated scaffolds for GPCR-mediated signaling. Growing

SUBMITTER: Peterson YK 

PROVIDER: S-EPMC5482185 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature