Stability and function of regulatory T cells expressing the transcription factor T-bet.

ABSTRACT: Adaptive immune responses are tailored to different types of pathogens through differentiation of naive CD4 T cells into functionally distinct subsets of effector T cells (T helper 1 (T_H1), T_H2, and T_H17) defined by expression of the key transcription factors T-bet, GATA3, and RORγt, respectively. Regulatory T (T_reg) cells comprise a distinct anti-inflammatory lineage specified by the X-linked transcription factor Foxp3 (refs 2, 3). Paradoxically, some activated T_reg cells express the aforementioned effector CD4 T cell transcription factors, which have been suggested to provide T_reg cells with enhanced suppressive capacity. Whether expression of these factors in T_reg cells-as in effector T cells-is indicative of h

SUBMITTER: Levine AG 

PROVIDER: S-EPMC5482236 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature