Outcomes in Pediatric Autoimmune Hepatitis and Significance of Azathioprine Metabolites.

ABSTRACT:

Objectives

Autoimmune hepatitis (AIH) is a common pediatric liver disease and long-term remission is usually maintained with azathioprine (AZA). There is no consensus on the target range for AZA active metabolite 6-thioguanine (6-TGN) levels in pediatric AIH. The aim of the present study was to characterize the outcomes of pediatric patients with AIH and determine correlations between AZA dosing or 6-TGN metabolite levels and biochemical remission.

Methods

A retrospective chart review was performed and data on presentation, laboratories including AZA metabolite levels, medication use, and outcomes were collected.

Results

Between 2002 and 2013, 66 children with AIH were identified (mean age at diagnosis 9.6 ± 5.1 years) with a mean follow-up period of 2.9 ± 3.2 years.

SUBMITTER: Sheiko MA 

PROVIDER: S-EPMC5482766 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature