Interaction of chronic food restriction and methylphenidate in sensation seeking of rats.

ABSTRACT:

Rationale

It is necessary to understand better how chronic food restriction (CFR) and psychostimulant drugs interact in motivated behavior unrelated to food or energy homeostasis.

Objectives

We examined whether CFR augments methylphenidate (MPH)-potentiated responding reinforced by visual sensation (VS) and whether repeated MPH injections or prolonged CFR further augments such responses.

Methods

Before starting the following experiments, rats on a CFR diet received a limited daily ration in such a way that their body weights decreased to 85-90% of their original weights over 2 weeks. In experiment 1, rats on CFR and ad libitum diet received four injections of varying MPH doses (0, 2.5, 5, and 10 mg/kg). In experiment 2, CFR and ad libitum groups received repeated inje

SUBMITTER: Talishinsky AD 

PROVIDER: S-EPMC5482769 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature