Myeloperoxidase Mediates Postischemic Arrhythmogenic Ventricular Remodeling.

ABSTRACT:

Rationale

Ventricular arrhythmias remain the leading cause of death in patients suffering myocardial ischemia. Myeloperoxidase, a heme enzyme released by polymorphonuclear neutrophils, accumulates within ischemic myocardium and has been linked to adverse left ventricular remodeling.

Objective

To reveal the role of myeloperoxidase for the development of ventricular arrhythmias.

Methods and results

In different murine models of myocardial ischemia, myeloperoxidase deficiency profoundly decreased vulnerability for ventricular tachycardia on programmed right ventricular and burst stimulation and spontaneously as assessed by ECG telemetry after isoproterenol injection. Experiments using CD11b/CD18 integrin-deficient (CD11b^-/-) mice and intravenous myeloperoxidas

SUBMITTER: Mollenhauer M 

PROVIDER: S-EPMC5482785 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature