News on the molecular regulation and function of hepatic low-density lipoprotein receptor and LDLR-related protein 1.

ABSTRACT:

Purpose of review

Clearing of atherogenic lipoprotein particles by the liver requires hepatic low-density lipoprotein receptor (LDLR) and LDLR-related protein 1 (LRP1). This review highlights recent studies that have expanded our understanding of the molecular regulation and metabolic functions of LDLR and LRP1 in the liver.

Recent findings

Various proteins orchestrate the intracellular trafficking of LDLR and LRP1. After internalization, the receptors are redirected via recycling endosomes to the cell surface. Several new endocytic proteins that facilitate the endosomal trafficking of LDLR and consequently the clearance of circulating LDL cholesterol have recently been reported. Mutations in some of these proteins cause hypercholesterolemia in human. In addition, LRP1 contr

SUBMITTER: van de Sluis B 

PROVIDER: S-EPMC5482905 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature