Evolution of the vertebrate insulin receptor substrate (Irs) gene family.

ABSTRACT:

Background

Insulin receptor substrate (Irs) proteins are essential for insulin signaling as they allow downstream effectors to dock with, and be activated by, the insulin receptor. A family of four Irs proteins have been identified in mice, however the gene for one of these, IRS3, has been pseudogenized in humans. While it is known that the Irs gene family originated in vertebrates, it is not known when it originated and which members are most closely related to each other. A better understanding of the evolution of Irs genes and proteins should provide insight into the regulation of metabolism by insulin.

Results

Multiple genes for Irs proteins were identified in a wide variety of vertebrate species. Phylogenetic and genomic neighborhood analyses indicate that this gene fam

SUBMITTER: Al-Salam A 

PROVIDER: S-EPMC5482937 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature