Cytogenetic abnormalities and fragile-X syndrome in Autism Spectrum Disorder.

ABSTRACT:

Background

Autism is a behavioral disorder with impaired social interaction, communication, and repetitive and stereotypic behaviors. About 5-10 % of individuals with autism have 'secondary' autism in which an environmental agent, chromosome abnormality, or single gene disorder can be identified. Ninety percent have idiopathic autism and a major gene has not yet been identified. We have assessed the incidence of chromosome abnormalities and Fragile X syndrome in a population of autistic patients referred to our laboratory.

Methods

Data was analyzed from 433 patients with autistic traits tested using chromosome analysis and/or fluorescence in situ hybridization (FISH) and/or molecular testing for fragile X syndrome by Southern and PCR methods.

Results

The median age wa

SUBMITTER: Reddy KS 

PROVIDER: S-EPMC548305 | biostudies-literature | 2005 Jan

REPOSITORIES: biostudies-literature