Functional Interactions between Newborn and Mature Neurons Leading to Integration into Established Neuronal Circuits.

ABSTRACT: From development up to adulthood, the vertebrate brain is continuously supplied with newborn neurons that integrate into established mature circuits. However, how this process is coordinated during development remains unclear. Using two-photon imaging, GCaMP5 transgenic zebrafish larvae, and sparse electroporation in the larva's optic tectum, we monitored spontaneous and induced activity of large neuronal populations containing newborn and functionally mature neurons. We observed that the maturation of newborn neurons is a 4-day process. Initially, newborn neurons showed undeveloped dendritic arbors, no neurotransmitter identity, and were unresponsive to visual stimulation, although they displayed spontaneous calcium transients. Later on, newborn-labeled neurons began to respond to visual

SUBMITTER: Boulanger-Weill J 

PROVIDER: S-EPMC5483231 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature