SBMLmod: a Python-based web application and web service for efficient data integration and model simulation.

ABSTRACT:

Background

Systems Biology Markup Language (SBML) is the standard model representation and description language in systems biology. Enriching and analysing systems biology models by integrating the multitude of available data, increases the predictive power of these models. This may be a daunting task, which commonly requires bioinformatic competence and scripting.

Results

We present SBMLmod, a Python-based web application and service, that automates integration of high throughput data into SBML models. Subsequent steady state analysis is readily accessible via the web service COPASIWS. We illustrate the utility of SBMLmod by integrating gene expression data from different healthy tissues as well as from a cancer dataset into a previously published model of mammalian tryptop

SUBMITTER: Schauble S 

PROVIDER: S-EPMC5483284 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature