Fine-mapping host genetic variation underlying outcomes to Mycobacterium bovis infection in dairy cows.

ABSTRACT:

Background

Susceptibility to Mycobacterium bovis infection in cattle is governed in part by host genetics. However, cattle diagnosed as infected with M. bovis display varying signs of pathology. The variation in host response to infection could represent a continuum since time of exposure or distinct outcomes due to differing pathogen handling. The relationships between host genetics and variation in host response and pathological sequelae following M. bovis infection were explored by genotyping 1966 Holstein-Friesian dairy cows at 538,231 SNPs with three distinct phenotypes. These were: single intradermal cervical comparative tuberculin (SICCT) test positives with visible lesions (VLs), SICCT-positives with undetected visible lesions (NVLs) and matched controls SICCT-negative on m

SUBMITTER: Wilkinson S 

PROVIDER: S-EPMC5483290 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature