Scattered genomic amplification in dedifferentiated liposarcoma.

ABSTRACT:

Background

Atypical lipomatous tumor (ALT), well differentiated liposarcoma (WDLS) and dedifferentiated liposarcoma (DDLS) are cytogenetically characterized by near-diploid karyotypes with no or few other aberrations than supernumerary ring or giant marker chromosomes, although DDLS tend to have somewhat more complex rearrangements. In contrast, pleomorphic liposarcomas (PLS) have highly aberrant and heterogeneous karyotypes. The ring and giant marker chromosomes contain discontinuous amplicons, in particular including multiple copies of the target genes CDK4, HMGA2 and MDM2 from 12q, but often also sequences from other chromosomes.

Results

The present study presents a DDLS with an atypical hypertriploid karyotype without any ring or giant marker chromos

SUBMITTER: Mandahl N 

PROVIDER: S-EPMC5483303 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature