Usefulness of limited sampling strategy for mycophenolic acid area under the curve considering postoperative days in living-donor renal transplant recipients with concomitant prolonged-release tacrolimus.

ABSTRACT:

Background

The optimal dose of mycophenolate mofetil (MMF) in renal transplant patients has been recommended to be decided on the basis of area under the concentration-time curve (AUC_0-12) of mycophenolic acid (MPA). Although meta-analysis has revealed that postoperative day (POD) is an influencing factor in MPA pharmacokinetics, there are no reports regarding a limited sampling strategy (LSS) for MPA AUC in consideration of POD. The aim of this study was to construct of an LSS considering POD that appropriately expresses the MPA AUC following renal transplantation and evaluation of the usefulness.

Methods

Serum concentration-time profiles (measured AUC_0-12) comprising nine sampling points over 12 h were analyzed in 36 living-donor renal transplant reci

SUBMITTER: Enokiya T 

PROVIDER: S-EPMC5483304 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature