Serum Asymmetric and Symmetric Dimethylarginine and Morbidity and Mortality in Hemodialysis Patients.

ABSTRACT:

Background

Asymmetric (ADMA) and symmetric dimethylarginine (SDMA) are putative uremic toxins that may exert toxicity by a number of mechanisms, including impaired nitric oxide synthesis and generation of reactive oxygen species. The study goal was to determine the association between these metabolites and cardiovascular outcomes in hemodialysis patients.

Study design

Post hoc analysis of the Hemodialysis (HEMO) Study.

Setting & participants

1,276 prevalent hemodialysis patients with available samples 3 to 6 months after randomization.

Predictor

ADMA and SDMA measured in stored specimens.

Outcomes

Cardiac death, sudden cardiac death, first cardiovascular event, and any-cause death. Association with predictors analyzed using Cox regression adjusted for po

SUBMITTER: Shafi T 

PROVIDER: S-EPMC5483385 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature