Ontology highlight
ABSTRACT:
SUBMITTER: Tsuyama T
PROVIDER: S-EPMC548366 | biostudies-literature | 2005
REPOSITORIES: biostudies-literature
Tsuyama Takashi T Tada Shusuke S Watanabe Saori S Seki Masayuki M Enomoto Takemi T
Nucleic acids research 20050201 2
Replication origins are licensed for a single initiation event by the loading of Mcm2-7 proteins during late mitosis and G1. Sequential associations of origin recognition complex, Cdc6 and Mcm2-7 are essential for completion of the licensing. Although Cdt1 also binds to the chromatin when the licensing reaction takes place, whether the binding is a requirement for Cdt1 to function is unclear. To analyze the relevance of the chromatin association of Cdt1, we carried out chromatin transfer experim ...[more]