Late Systolic Myocardial Loading Is Associated With Left Atrial Dysfunction in Hypertension.

ABSTRACT:

Background

Late systolic load has been shown to cause diastolic dysfunction in animal models. Although the systolic loading sequence of the ventricular myocardium likely affects its coupling with the left atrium (LA), this issue has not been investigated in humans. We aimed to assess the relationship between the myocardial loading sequence and LA function in human hypertension.

Methods and results

We studied 260 subjects with hypertension and 19 normotensive age- and sex-matched controls. Time-resolved central pressure and left ventricular geometry were measured with carotid tonometry and cardiac magnetic resonance imaging, respectively, for computation of time-resolved ejection-phase myocardial wall stress (MWS). The ratio of late/early ejection-phase MWS time integrals was

SUBMITTER: Chirinos JA 

PROVIDER: S-EPMC5484079 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature