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Trichodermanins C-E, New Diterpenes with a Fused 6-5-6-6 Ring System Produced by a Marine Sponge-Derived Fungus.

ABSTRACT: Trichodermanins C-E (1-3), new diterpenes with a rare fused 6-5-6-6 ring system, have been isolated from a fungus Trichoderma harzianum OUPS-111D-4 separated from a piece of a marine sponge Halichondria okadai, and these chemical structures have been established by spectroscopic analyses using IR, MASS, HRFABMS, and NMR spectra. We established their absolute stereostructures by application of the modified Mosher's method. In addition, 1 inhibited the growth of cancer cell lines potently.

SUBMITTER: Yamada T 

PROVIDER: S-EPMC5484119 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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Trichodermanins C-E, New Diterpenes with a Fused 6-5-6-6 Ring System Produced by a Marine Sponge-Derived Fungus.

Yamada Takeshi T   Suzue Mayo M   Arai Takanobu T   Kikuchi Takashi T   Tanaka Reiko R  

Marine drugs 20170609 6

Trichodermanins C-E (<b>1</b>-<b>3</b>), new diterpenes with a rare fused 6-5-6-6 ring system, have been isolated from a fungus <i>Trichoderma harzianum</i> OUPS-111D-4 separated from a piece of a marine sponge <i>Halichondria okadai</i>, and these chemical structures have been established by spectroscopic analyses using IR, MASS, HRFABMS, and NMR spectra. We established their absolute stereostructures by application of the modified Mosher's method. In addition, <b>1</b> inhibited the growth of  ...[more]

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