A genome-wide association scan of biological processes involved in oral lichen planus and oral squamous cell carcinoma.

ABSTRACT:

Background

In this study, the molecular mechanisms underlying malignant transformation from oral lichen planus (OLP) to oral squamous cell carcinoma (OSCC) were examined.

Methods

High-throughput sequencing of long noncoding RNAs (lncRNAs) and mRNAs of normal subjects and patients with OLP and OSCC was conducted. RNA-seq reads were mapped, lncRNA and mRNA transcripts were assembled, and expression levels were estimated. The targets of lncRNAs were predicted. Finally, Gene Ontology (GO) and pathway enrichment analyses of differentially expressed genes (DEGs) and lncRNA targets were performed.

Results

High-quality sequence data were generated and the mapping ratios for OSCC, normal, and OLP samples were high. In total, 820, 656, and 582 DEGs were obtained from OPL vs. no

SUBMITTER: Yang Q 

PROVIDER: S-EPMC5484187 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature