Prognostic impact of Ki-67 in patients with gastric cancer-the importance of depth of invasion and histologic differentiation.

ABSTRACT: Ki-67 protein is a cellular marker for proliferation. The role of Ki-67 as a prognostic biomarker has not been established in gastric cancer. The present study was performed to investigate the significance of Ki-67 expression as a biomarker in early gastric cancer (EGC).With tissue microarray for 320 patients with gastric cancer, we performed immunohistochemical staining for Ki-67. Its clinical significance was analyzed with adjustment via the propensity score-matching. For validation, we performed bootstrap resampling.The median follow-up duration was 72 months (range: 3-120 months). Ki-67-high group showed worse prognosis than Ki-67-low group in EGC (5-YSR, 78.9% vs 92.0%, P  =  .018), but not in advanced gastric cancer (AGC) (5-YSR, 58.5% vs 59.2%, P  =  .951). Interestingly, in the pat

SUBMITTER: Ko GH 

PROVIDER: S-EPMC5484207 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature