Reproducibility of quantitative indices of lung function and microstructure from ¹²⁹ Xe chemical shift saturation recovery (CSSR) MR spectroscopy.

ABSTRACT:

Purpose

To evaluate the reproducibility of indices of lung microstructure and function derived from ¹²⁹ Xe chemical shift saturation recovery (CSSR) spectroscopy in healthy volunteers and patients with chronic obstructive pulmonary disease (COPD), and to study the sensitivity of CSSR-derived parameters to pulse sequence design and lung inflation level.

Methods

Preliminary data were collected from five volunteers on three occasions, using two implementations of the CSSR sequence. Separately, three volunteers each underwent CSSR at three different lung inflation levels. After analysis of these preliminary data, five COPD patients were scanned on three separate days, and nine age-matched volunteers were scanned three times on one day, to assess reproducibility.

Re

SUBMITTER: Stewart NJ 

PROVIDER: S-EPMC5484314 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature