Optimization of simultaneous multislice EPI for concurrent functional perfusion and BOLD signal measurements at 7T.

ABSTRACT:

Purpose

To overcome limitations of previous ultra-high-field arterial spin labeling (ASL) techniques concerning temporal resolution and brain coverage by utilizing the simultaneous multi-slice (SMS) approach.

Methods

An optimized, flow-alternating inversion recovery quantitative imaging of perfusion using a single subtraction II scheme was developed that tackles the challenges of 7 tesla (T) ASL. The implementation of tailored labeling radiofrequency pulses reduced the effect of transmit field ( B1+) inhomogeneities. The proposed approach utilizes an SMS echo-planar imaging (EPI) readout to efficiently achieve large brain coverage.

Results

A pulsed ASL (PASL) technique with large brain coverage is described and optimized that can be applied at temporal resolutions bel

SUBMITTER: Ivanov D 

PROVIDER: S-EPMC5484334 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature