Comparison of linear and nonlinear implementation of the compartmental tissue uptake model for dynamic contrast-enhanced MRI.

ABSTRACT:

Purpose

Fitting tracer kinetic models using linear methods is much faster than using their nonlinear counterparts, although this comes often at the expense of reduced accuracy and precision. The aim of this study was to derive and compare the performance of the linear compartmental tissue uptake (CTU) model with its nonlinear version with respect to their percentage error and precision.

Theory and methods

The linear and nonlinear CTU models were initially compared using simulations with varying noise and temporal sampling. Subsequently, the clinical applicability of the linear model was demonstrated on 14 patients with locally advanced cervical cancer examined with dynamic contrast-enhanced magnetic resonance imaging.

Results

Simulations revealed equal percentage erro

SUBMITTER: Kallehauge JF 

PROVIDER: S-EPMC5484345 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature