Creatine kinase rate constant in the human heart measured with 3D-localization at 7 tesla.

ABSTRACT:

Purpose

We present a new Bloch-Siegert four Angle Saturation Transfer (BOAST) method for measuring the creatine kinase (CK) first-order effective rate constant k_f in human myocardium at 7 tesla (T). BOAST combines a variant of the four-angle saturation transfer (FAST) method using amplitude-modulated radiofrequency pulses, phosphorus Bloch-Siegert B1+-mapping to determine the per-voxel flip angles, and nonlinear fitting to Bloch simulations for postprocessing.

Methods

Optimal flip angles and repetition time parameters were determined from Monte Carlo simulations. BOAST was validated in the calf muscle of two volunteers at 3T and 7T. The myocardial CK forward rate constant was then measured in 10 volunteers at 7T in 82 min (after ¹ H localization).

Re

SUBMITTER: Clarke WT 

PROVIDER: S-EPMC5484353 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature