Goodness of fit tools for dose-response meta-analysis of binary outcomes.

ABSTRACT: Goodness of fit evaluation should be a natural step in assessing and reporting dose-response meta-analyses from aggregated data of binary outcomes. However, little attention has been given to this topic in the epidemiological literature, and goodness of fit is rarely, if ever, assessed in practice. We briefly review the two-stage and one-stage methods used to carry out dose-response meta-analyses. We then illustrate and discuss three tools specifically aimed at testing, quantifying, and graphically evaluating the goodness of fit of dose-response meta-analyses. These tools are the deviance, the coefficient of determination, and the decorrelated residuals-versus-exposure plot. Data from two published meta-analyses are used to show how these three tools can improve the practice of quantitativ

SUBMITTER: Discacciati A 

PROVIDER: S-EPMC5484373 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature