Meta-analysis of miRNA expression profiles for prostate cancer recurrence following radical prostatectomy.

ABSTRACT:

Background

Prostate cancer (PCa) is a leading reason of death in men and the most diagnosed malignancies in the western countries at the present time. After radical prostatectomy (RP), nearly 30% of men develop clinical recurrence with high serum prostate-specific antigen levels. An important challenge in PCa research is to identify effective predictors of tumor recurrence. The molecular alterations in microRNAs are associated with PCa initiation and progression. Several miRNA microarray studies have been conducted in recurrence PCa, but the results vary among different studies.

Methods

We conducted a meta-analysis of 6 available miRNA expression datasets to identify a panel of co-deregulated miRNA genes and overlapping biological processes. The meta-analysis was performed u

SUBMITTER: Pashaei E 

PROVIDER: S-EPMC5484492 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature