Acute rejection after kidney transplantation promotes graft fibrosis with elevated adenosine level in rat.

ABSTRACT:

Aims

Chronic allograft nephropathy is a worldwide issue with the major feature of progressive allograft fibrosis, eventually ending with graft loss. Adenosine has been demonstrated to play an important role in process of fibrosis. Our study aimed to investigate the relationship between adenosine and fibrosis in renal allograft acute rejection in rat.

Materials and methods

Wistar rats and SD rats were selected as experimental animals. Our study designed two groups. In the allograft transplantation group, kidneys of Wistar rats were orthotopically transplanted into SD rat recipients, the same species but not genetically identical, to induce acute rejection. Kidney transplantations of SD rats to SD rats which were genetically identical were served as the control. We established

SUBMITTER: Li M 

PROVIDER: S-EPMC5484506 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature