Freezing of gait is an early clinical feature of progressive supranuclear palsy.

ABSTRACT:

Background and aim

Early clinical diagnosis of progressive supranuclear palsy (PSP) remains challenging.

Aim

We attempted to identify any sign or symptom to diagnose PSP earlier.

Methods

A total of 401 patients, 40 with PSP and 361 with other neurodegenerative disorders, were included. We followed these patients for at least 1 year since 2009. We reviewed the signs and symptoms of patients with PSP in a standardized manner, and observed four manifestations: "vertical supranuclear gaze abnormality," "movement disorders," "pseudobulbar palsy" and "dementia of frontal type." Features, such as symmetric parkinsonism, freezing of gait, postural instability, dysarthria and/or dysphagia, or dementia of frontal type, were considered core clinical features.

Results

In p

SUBMITTER: Osaki Y 

PROVIDER: S-EPMC5484990 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature