Dual hypothermic oxygenated machine perfusion in liver transplants donated after circulatory death.

ABSTRACT:

Background

Experimental studies have suggested that end-ischaemic dual hypothermic oxygenated machine perfusion (DHOPE) may restore hepatocellular energy status and reduce reperfusion injury in donation after circulatory death (DCD) liver grafts. The aim of this prospective case-control study was to assess the safety and feasibility of DHOPE in DCD liver transplantation.

Methods

In consecutive DCD liver transplantations, liver grafts were treated with end-ischaemic DHOPE. Outcome was compared with that in a control group of DCD liver transplantations without DHOPE, matched for donor age, donor warm ischaemia time, and recipient Model for End-stage Liver Disease (MELD) score. All patients were followed for 1 year.

Results

Ten transplantations involving liver grafts tre

SUBMITTER: van Rijn R 

PROVIDER: S-EPMC5484999 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature