Dissecting the PhoP regulatory network of Escherichia coli and Salmonella enterica.

ABSTRACT: Genetic and genomic approaches have been successfully used to assign genes to distinct regulatory networks. However, the present challenge of distinguishing differentially regulated genes within a network is particularly hard because members of a given network tend to have similar regulatory features. We have addressed this challenge by developing a method, termed Gene Promoter Scan, that discriminates coregulated promoters by simultaneously considering both multiple cis promoter features and gene expression. Here, we apply this method to probe the regulatory networks governed by the PhoP/PhoQ two-component system in the enteric bacteria Escherichia coli and Salmonella enterica. Our analysis uncovered members of the PhoP regulon and interactions with other regulatory systems that were not

SUBMITTER: Zwir I 

PROVIDER: S-EPMC548500 | biostudies-literature | 2005 Feb

REPOSITORIES: biostudies-literature