Mutagenicity testing with transgenic mice. Part II: Comparison with the mouse spot test.

ABSTRACT: The mouse spot test, an in vivo mutation assay, has been used to assess a number of chemicals. It is at present the only in vivo mammalian test system capable of detecting somatic gene mutations according to OECD guidelines (OECD guideline 484). It is however rather insensitive, animal consuming and expensive type of test. More recently several assays using transgenic animals have been developed. From data in the literature, the present study compares the results of in vivo testing of over twenty chemicals using the mouse spot test and compares them with results from the two transgenic mouse models with the best data base available, the lacI model (commercially available as the Big Blue(R) mouse), and the lacZ model (commercially available as the Mutatrade mark Mouse). There was agreement

SUBMITTER: Wahnschaffe U 

PROVIDER: S-EPMC548508 | biostudies-literature | 2005 Jan

REPOSITORIES: biostudies-literature