Association of the NuMA region on chromosome 11q13 with breast cancer susceptibility.

ABSTRACT: The development of breast cancer is a complex process that involves multiple genes at many stages, from initial cell cycle dysregulation to disease progression. To identify genetic variations that influence this process, we conducted a large-scale association study using a collection of German cases and controls and >25,000 SNPs located within 16,000 genes. One of the loci identified was located on chromosome 11q13 [odds ratio (OR)=1.85, P=0.017]. The initial association was subsequently tested in two independent breast cancer collections. In both sample sets, the frequency of the susceptibility allele was increased in the cases (OR=1.6, P=0.01). The susceptibility allele was also associated with an increase in cancer family history (P=0.1). Fine mapping showed that the region of associati

SUBMITTER: Kammerer S 

PROVIDER: S-EPMC548529 | biostudies-literature | 2005 Feb

REPOSITORIES: biostudies-literature