Clinical characteristics and outcomes according to age in lenalidomide-treated patients with RBC transfusion-dependent lower-risk MDS and del(5q).

ABSTRACT: BACKGROUND:Particularly since the advent of lenalidomide, lower-risk myelodysplastic syndromes (MDS) patients with del(5q) have been the focus of many studies; however, the impact of age on disease characteristics and response to lenalidomide has not been analyzed. METHODS:We assessed the effect of age on clinical characteristics and outcomes in 286 lenalidomide-treated MDS patients with del(5q) from two multicenter trials. RESULTS:A total of 33.9, 34.3, and 31.8% patients were aged <65 years, ?65 to <75 years, and ?75 years, respectively. Age <65 years was associated with less favorable International Prognostic Scoring System (IPSS) risk and additional cytopenias at baseline versus older age groups, significantly lower cytogenetic response rates (p?=?0.022 vs. ?65 to <75 years; p?=?0.047 vs. ?75 years), and higher rates of acute myeloid leukemia (AML) progression (Gray's test, p?=?0.013). Lenalidomide was equally well tolerated across age groups, producing consistently high rates of red blood cell transfusion independence ?26 weeks. CONCLUSIONS:Baseline disease characteristics and AML progression appear to be more severe in younger lower-risk MDS patients with del(5q), whereas older age does not seem to compromise the response to lenalidomide. TRIAL REGISTRATION:ClinicalTrials.gov NCT00065156 and NCT00179621.

SUBMITTER: Fenaux P 

PROVIDER: S-EPMC5485496 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature