Adult cancer-related hemophagocytic lymphohistiocytosis - a challenging diagnosis: a case report.

ABSTRACT:

Background

Adult hemophagocytic lymphohistiocytosis is a secondary immunopathologic phenomenon, mainly secondary to malignancy, infection, or autoimmune disorders. The performance of diagnostic criteria, studied in the pediatric population, is yet to be validated in the adult population. Some of the criteria include cytopenias and organomegaly that are inherent features to malignant processes, thus making the diagnosis of hemophagocytic lymphohistiocytosis a challenge in patients with cancer.

Case presentation

We describe the case of a 54-year-old white man with history of metastatic maxillary sinus adenoid cystic carcinoma who had severe liver injury and cytopenias with progressive clinical deterioration. We performed an evaluation, by flow cytometry, of the expression of s

SUBMITTER: Hust MA 

PROVIDER: S-EPMC5485603 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature