The CD4+ T cell regulatory network mediates inflammatory responses during acute hyperinsulinemia: a simulation study.

ABSTRACT:

Background

Obesity is frequently linked to insulin resistance, high insulin levels, chronic inflammation, and alterations in the behaviour of CD4+ T cells. Despite the biomedical importance of this condition, the system-level mechanisms that alter CD4+ T cell differentiation and plasticity are not well understood.

Results

We model how hyperinsulinemia alters the dynamics of the CD4+ T regulatory network, and this, in turn, modulates cell differentiation and plasticity. Different polarizing microenvironments are simulated under basal and high levels of insulin to assess impacts on cell-fate attainment and robustness in response to transient perturbations. In the presence of high levels of insulin Th1 and Th17 become more stable to transient perturbations, and their basin size

SUBMITTER: Martinez-Sanchez ME 

PROVIDER: S-EPMC5485658 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature