Base Catalysis Enables Access to α,α-Difluoroalkylthioethers.

ABSTRACT: A nucleophilic addition reaction of aryl thiols to readily available β,β-difluorostyrenes provides α,α-difluoroalkylthioethers. The reaction proceeds through an unstable anionic intermediate, prone to eliminate fluoride and generate α-fluorovinylthioethers. However, the use of base catalysis overcomes the facile β-fluoride elimination, generating α,α-difluoroalkylthioethers in excellent yields and selectivities.

SUBMITTER: Orsi DL 

PROVIDER: S-EPMC5485667 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature