Induction of endoplasmic reticulum calcium pump expression during early leukemic B cell differentiation.

ABSTRACT:

Background

Endoplasmic reticulum (ER) calcium storage and release play important roles in B lymphocyte maturation, survival, antigen-dependent cell activation and immunoglobulin synthesis. Calcium is accumulated in the endoplasmic reticulum (ER) by Sarco/Endoplasmic Reticulum Calcium ATPases (SERCA enzymes). Because lymphocyte function is critically dependent on SERCA activity, it is important to understand qualitative and quantitative changes of SERCA protein expression that occur during B lymphoid differentiation and leukemogenesis.

Methods

In this work we investigated the modulation of SERCA expression during the pharmacologically induced differentiation of leukemic precursor B lymphoblast cell lines that carry the E2A-PBX1 fusion oncoprotein. Changes of SERCA levels duri

SUBMITTER: Ait Ghezali L 

PROVIDER: S-EPMC5485704 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature