Identifying global expression patterns and key regulators in epithelial to mesenchymal transition through multi-study integration.

ABSTRACT:

Background

Epithelial to mesenchymal transition (EMT) is the process by which stationary epithelial cells transdifferentiate to mesenchymal cells with increased motility. EMT is integral in early stages of development and wound healing. Studies have shown that EMT could be a critical early event in tumor metastasis that is involved in acquisition of migratory and invasive properties in multiple carcinomas.

Methods

In this study, we used 15 published gene expression microarray datasets from Gene Expression Omnibus (GEO) that represent 12 cell lines from 6 cancer types across 95 observations (45 unique samples and 50 replicates) with different modes of induction of EMT or the reverse transition, mesenchymal to epithelial transition (MET). We integrated multiple gene expression

SUBMITTER: Parsana P 

PROVIDER: S-EPMC5485747 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature