Deficiency of LRP1 in Mature Adipocytes Promotes Diet-Induced Inflammation and Atherosclerosis-Brief Report.

ABSTRACT:

Objective

Mice with adipocyte-specific inactivation of low-density lipoprotein receptor-related protein-1 (LRP1) are resistant to diet-induced obesity and hyperglycemia because of compensatory thermogenic response by muscle. However, the physiological function of LRP1 in mature adipocytes and its role in cardiovascular disease modulation are unknown. This study compared perivascular adipose tissues (PVAT) from wild-type (adLrp1^+/+) and adipocyte-specific LRP1 knockout (adLrp1^-/-) mice in modulation of atherosclerosis progression.

Approach and results

Analysis of adipose tissues from adLrp1^+/+ and adLrp1^-/- mice after Western diet feeding for 16 weeks revealed that, in comparison to adLrp1^+/+<

SUBMITTER: Konaniah ES 

PROVIDER: S-EPMC5485832 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature