TAM Receptors Are Not Required for Zika Virus Infection in Mice.

ABSTRACT: Tyro3, Axl, and Mertk (TAM) receptors are candidate entry receptors for infection with the Zika virus (ZIKV), an emerging flavivirus of global public health concern. To investigate the requirement of TAM receptors for ZIKV infection, we used several routes of viral inoculation and compared viral replication in wild-type versus Axl^-/-, Mertk^-/-, Axl^-/-Mertk^-/-, and Axl^-/-Tyro3^-/- mice in various organs. Pregnant and non-pregnant mice treated with interferon-α-receptor (IFNAR)-blocking (MAR1-5A3) antibody and infected subcutaneously with ZIKV showed no reliance on TAMs for infection. In the absence of IFNAR-blocking antibody, adult female mice challenged intravaginally with ZIKV showed no difference in mucosal viral titers. Si

SUBMITTER: Hastings AK 

PROVIDER: S-EPMC5485843 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature